Journal article

Concurrent Validity and Reliability of Suicide Risk Assessment Instruments: A Meta-Analysis of 20 Instruments Across 27 International Cohorts

AI Campos, LS van Velzen, DJ Veltman, E Pozzi, S Ambrogi, ED Ballard, N Banaj, Z Başgöze, S Bellow, F Benedetti, I Bollettini, K Brosch, EJ Canales-Rodríguez, EK Clarke-Rubright, L Colic, CG Connolly, P Courtet, KR Cullen, U Dannlowski, MR Dauvermann Show all

Neuropsychology | Published : 2023

Abstract

Objective: A major limitation of current suicide research is the lack of power to identify robust correlates of suicidal thoughts or behavior. Variation in suicide risk assessment instruments used across cohorts may represent a limitation to pooling data in international consortia. Method: Here, we examine this issue through two approaches: (a) an extensive literature search on the reliability and concurrent validity of the most commonly used instruments and (b) by pooling data (N ∼ 6,000 participants) from cohorts from the Enhancing NeuroImaging Genetics Through Meta-Analysis (ENIGMA) Major Depressive Disorder and ENIGMA–Suicidal Thoughts and Behaviour working groups, to assess the concurre..

View full abstract

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC) Centre for Research Excellence on Suicide Prevention


Awarded by National Institute of Mental Health (NIMH) of the National Institutes of Health (NIH)


Awarded by NHMRC


Awarded by American Foundation for Suicide Prevention (AFSP)


Awarded by Centro de Investigacion Biomedica En Red of Mental Health


Awarded by Instituto de Salud Carlos III (ISCIII)


Awarded by Italian Ministry of Health Grant


Awarded by Leiden University Social Safety and Resilience Programme


Awarded by Phyllis and Jerome Lyle Rappaport Foundation


Awarded by National Alliance for Research on Schizophrenia and Depression


Awarded by University of Minnesota


Awarded by ISCIII-Subdireccion General de Evaluacion


Awarded by CERCA Programme


Awarded by European Union


Awarded by "La Caixa" Foundation


Awarded by Klingenstein Third Generation Foundation


Awarded by National Center for Advancing Translational Sciences (Clinical and Translational Science Institute), NIH, through UCSF-CTSI


Awarded by AFSP


Awarded by UCSF Research Evaluation and Allocation Committee


Awarded by Interdisciplinary Center for Clinical Research (Interdisziplinaere Zentrum fir Klinische Forschung) of the medical faculty of Minster


Awarded by NHMRC of Australia


Awarded by NCCIH


Awarded by National Institutes Health



Funding Acknowledgements

Miguel E. Renteria received support from the Australian National Health and Medical Research Council (NHMRC) Centre for Research Excellence on Suicide Prevention (Grant GNT1042580). Lianne Schmaal, Laura S. Van Velzen, Lejla Colic, Hilary P. Blumberg, Anne-Laura van Harmelen, Sophie Bellow, and Maria R. Dauvermann were supported by the MQ Brighter Futures Award MQBFC/2. Laura S. Van Velzen, Lianne Schmaal, and Neda Jahanshad were supported by the National Institute of Mental Health (NIMH) of the National Institutes of Health (NIH) under Award Number R01MH117601. Lianne Schmaal is supported by an NHMRC Career Development Fellowship (Grant 1140764). Hilary P. Blumberg was additionally supported by R61MH111929, RC1MH088366, R01MH070902, R01MH069747, American Foundation for Suicide Preven-tion (AFSP), International Bipolar Foundation, Brain and Behavior Research Foundation, For the Love of Travis Foundation, and Women's Health Research at Yale. Lejla Colic was additionally supported by Interdisziplinaeres Zentrum fir Klinische Forschung, Universitaetsklinikum Jena. Paul M. Thomp-son was supported in part by NIH Grant R01 MH116147. Fabrice Jollant would like to thank S. Richard-Devantoy for his assistance during data collection. This work was supported by the Centro de Investigacio'n Biomedica En Red of Mental Health and the Catalonian Government (2014-SGR-1573 and 2017-SGR-1271 to FIDMAG). Paola Fuentes-Claramonte is funded by the Instituto de Salud Carlos III (ISCIII), cofunded by European Union (European Regional Development Fund/European Social Fund "Investing in Your Future"): Sara Borrell contract (CD19/00149). The researchers based in Milan were supported by an Italian Ministry of Health Grant RF-2011-02349921. Anne-Laura van Harmelen was funded through the Leiden University Social Safety and Resilience Programme. The NIMH-Experimental Therapeutics & Pathophysiology Branch team was supported by the Intramural Research Program at the NIMH, NIH (IRP-NIMH-NIH; ZIAMH002927). Matthew D. Sacchet is supported by the Phyllis and Jerome Lyle Rappaport Foundation; Ad Astra Chandaria Foundation; BIAL Foundation; Brain and Behavior Research Foundation; anonymous donors; and the Center for Depression, Anxiety, and Stress Research at McLean Hospital. The team based at the University of Minnesota was supported by the NIMH (K23MH090421), the National Alliance for Research on Schizophrenia and Depression, the Univer-sity of Minnesota Graduate School, the Minnesota Medical Foundation, and the Biotechnology Research Center (P41 RR008079 to the Center for Mag-netic Resonance Research), University of Minnesota, and the Deborah E. Powell Center for Women's Health Seed Grant. Ian H. Gotlib was supported by the NIMH Grant R37MH101495. Eduard Vieta thanks the support of the Spanish Ministry of Science and Innovation (PI15/00283, PI18/00805) integrated into the Plan Nacional de I + D + I and cofinanced by the ISCIII-Subdireccion General de Evaluacion and the Fondo Europeo de Desarrollo Regional (FEDER); the ISCIII; the Centro de Investigacion Biomedica En Red of Mental Health; the Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2017-SGR-1365), the CERCA Programme, and the Departament de Salut de la Generalitat de Catalunya for the PERIS grant SLT006/17/00357. Norma Verdolini thanks the support of a BITRECS project that has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 754550 and from "La Caixa" Foundation (ID 100010434), under the agreement LCF/PR/GN18/50310006. For the team in Nimes, CINES grants access to high performance computing facilities (A0100311413). The team based in Rome was supported by an Italian Ministry of Health Grant RC17-18-19-20-21/A. Support for the TIGER study includes the Klingenstein Third Generation Foundation, the NIMH (K01MH117442), the Stanford Maternal Child Health Research Institute, and the Stanford Center for Cognitive and Neurobiological Imaging. Tiffany C. Ho receives partial support from the Ray and Dagmar Dolby Family Fund. The University of California, San Francisco (UCSF) site was supported by the National Center for Complementary and Integrative Health (NCCIH) R21AT009173 and R61AT009864 to Tony T. Yang; by the National Center for Advancing Translational Sciences (Clinical and Translational Science Institute), NIH, through UCSF-CTSI UL1TR001872 to Tony T. Yang; by the AFSP SRG-1-141-18 to Tony T. Yang; by UCSF Research Evaluation and Allocation Committee and J. Jacobson Fund to Tony T. Yang; by the NIMH R01MH085734 and the Brain and Behavior Research Foundation (formerly National Alliance for Research on Schizophrenia & Depression) to Tony T. Yang. The teams at Duke University/Durham Veteran Affairs medical center were supported by the Veteran Affairs Mid-Atlantic Mental Illness Research Education and Clinical Center. The Moral Dilemma study was supported by the Brain and Behavior Research Foundation and by the NHMRC (ID 1125504 to Sarah L. Whittle). The FOR2107 Marburg site was supported by the German Research Founda-tion/Deutsche Forschungsgemeinschaft (DFG, Grant FOR2107 KI588/14-1 and FOR2107 KI588/14-2 to Tilo Kircher, Marburg). The FOR2107 Muenster site was supported by the German Research Foundation/Deutsche Forschungsgemeinschaft (DFG, Grant FOR2107 DA1151/5-1 and DA1151/5-2 to Udo Dannlowski; SFB-TRR58, Projects C09 and Z02 to Udo Dannlowski) and the Interdisciplinary Center for Clinical Research (Interdisziplinaere Zentrum fir Klinische Forschung) of the medical faculty of Minster (Grant Dan3/012/17 to Udo Dannlowski). Christopher G. Davey and Ben J. Harrison were supported by the NHMRC of Australia Project Grants (1064643 and 1024570). Negar Fani was supported by the NIMH (MH111671) and NCCIH (R01AT011267). Tanja Jovanovic was supported by the National Institutes Health Project Grants (MH098212) to Tanja Jovanovic. Joaquim Radua and Lydia Fortea thank the support of the Spanish Ministry of Science and Innovation (PI19/00394 and CPII19/00009) integrated into the Plan Nacional de I + D + I and cofinanced by the ISCIII-Subdireccio'n General de Evaluacio'n and the FEDER; the ISCIII; the Centro de Investigacio'n Biomedica En Red of Mental Health. Yoshiyuki Hirano, Akiko Nakagawa, and Eiji Shimizu were supported by Agency of Medical Research and Development Brain/MINDS Beyond program Grant 20dm0307002, and Yoshiyuki Hirano was supported by Japan Society for the Promotion of Science Kakenhi Program Grants 19K03309. AFFDIS was funded by the University Medical Center Goettingen (UMG Startfoerderung); Tracy Erwin-Grabner and Roberto Goya-Maldonado were supported by German Federal Ministry of Education and Research (Bundesministerium fuer Bildung und Forschung, BMBF: 01 ZX 1507, "PreNeSt-e:Med").